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Candidate gene association studies: Successes and failures

Epidemiologic studies of twins indicate that 20-40% of common tumors such as breast, colorectal and prostate cancers are inherited. However, the effect of high penetrance tumor susceptibility genes such as APC, BRCA1, BRAC2, MSH1, MLH2 and MSH6 only accounts for a small fraction of these cancers. A...

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Библиографические подробности
Главные авторы: Pasche, Boris, Yi, Nengjun
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885524/
https://ncbi.nlm.nih.gov/pubmed/20417090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2010.03.006
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