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Inflammatory Skin Disease in K5.hTGF-β1 Transgenic Mice Is Not Dependent on the IL-23/Th17 Inflammatory Pathway

In the presence of IL-6, transforming growth factor (TGF)-β1 induces differentiation of T helper (Th) 17 cells in mice. Interleukin (IL)-23, a heterodimeric cytokine composed of IL-23p19 and IL-12/23p40 subunits, stimulates the growth and expansion of Th17 cells, and has been implicated in psoriasis...

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Main Authors: Fitch, Erin L., Rizzo, Heather L., Kurtz, Stephen E., Wegmann, Keith W., Gao, Wei, Benson, Jacqueline M., Hinrichs, David J., Blauvelt, Andrew
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885354/
https://ncbi.nlm.nih.gov/pubmed/19357708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2009.88
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