The evolutionary impact of androgen levels on prostate cancer in a multi-scale mathematical model

BACKGROUND: Androgens bind to the androgen receptor (AR) in prostate cells and are essential survival factors for healthy prostate epithelium. Most untreated prostate cancers retain some dependence upon the AR and respond, at least transiently, to androgen ablation therapy. However, the relationship...

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Bibliographic Details
Main Authors: Eikenberry, Steffen E, Nagy, John D, Kuang, Yang
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885348/
https://ncbi.nlm.nih.gov/pubmed/20406442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6150-5-24
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