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Phosphatidylinositol 4,5-Bisphosphate Activates Slo3 Currents and Its Hydrolysis Underlies the Epidermal Growth Factor-induced Current Inhibition

The Slo3 gene encodes a high conductance potassium channel, which is activated by both voltage and intracellular alkalinization. Slo3 is specifically expressed in mammalian sperm cells, where it gives rise to pH-dependent outwardly rectifying K(+) currents. Sperm Slo3 is the main current responsible...

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Detalhes bibliográficos
Main Authors: Tang, Qiong-Yao, Zhang, Zhe, Xia, Jingsheng, Ren, Dejian, Logothetis, Diomedes E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885204/
https://ncbi.nlm.nih.gov/pubmed/20392696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.100156
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