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CYP2E1 potentiation of LPS and TNFα-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction

The mechanisms by which alcohol causes cell injury are not clear. A major mechanism that is the focus of considerable research is the role of lipid peroxidation and oxidative stress in alcohol toxicity. Many pathways have been suggested to play a role in how alcohol induces oxidative stress. Conside...

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Autors principals: Lu, Yongke, Cederbaum, Arthur I.
Format: Artigo
Idioma:Inglês
Publicat: Springer-Verlag 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885169/
https://ncbi.nlm.nih.gov/pubmed/19798529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12263-009-0150-5
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