Inhibition of lipoprotein-associated phospholipase A(2) reduces complex coronary atherosclerotic plaque development

Increased lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activity is associated with increased risk of cardiac events, but it is not known whether Lp-PLA(2) is a causative agent. Here we show that selective inhibition of Lp-PLA(2) with darapladib reduced development of advanced coronary ather...

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Detalhes bibliográficos
Main Authors: Wilensky, Robert L, Shi, Yi, Mohler, Emile R, Hamamdzic, Damir, Burgert, Mark E, Li, Jun, Postle, Anthony, Fenning, Robert S, Bollinger, James G, Hoffman, Bryan E, Pelchovitz, Daniel J, Yang, Jisheng, Mirabile, Rosanna C, Webb, Christine L, Zhang, LeFeng, Zhang, Ping, Gelb, Michael H, Walker, Max C, Zalewski, Andrew, Macphee, Colin H
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885134/
https://ncbi.nlm.nih.gov/pubmed/18806801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1870
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