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Adeno-associated virus serotype 2 induces cell-mediated immune responses directed against multiple epitopes of the capsid protein VP1

Adeno-associated virus serotype 2 (AAV-2) has been developed as a gene therapy vector. Antibody and cell-mediated immune responses to AAV-2 or AAV-2-transfected cells may confound the therapeutic use of such vectors in clinical practice. In one of the most detailed examinations of AAV-2 immunity in...

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Bibliografiset tiedot
Päätekijät: Madsen, Declan, Cantwell, Emma R., O'Brien, Timothy, Johnson, Patricia A., Mahon, Bernard P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Society for General Microbiology 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885037/
https://ncbi.nlm.nih.gov/pubmed/19641045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.014175-0
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