Mumps virus Enders strain is sensitive to interferon (IFN) despite encoding a functional IFN antagonist

Although the Enders strain of mumps virus (MuV) encodes a functional V protein that acts as an interferon (IFN) antagonist, in multi-cycle growth assays MuV Enders grew poorly in naïve (‘IFN-competent’ Hep2) cells but grew to high titres in ‘IFN-compromised’ Hep2 cells. Even so, the growth rate of M...

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Bibliographic Details
Main Authors: Young, D. F., Galiano, M. C., Lemon, K., Chen, Y.-H., Andrejeva, J., Duprex, W. P., Rima, B. K., Randall, R. E.
Format: Artigo
Language:Inglês
Published: Society for General Microbiology 2009
Subjects:
Animal
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885035/
https://ncbi.nlm.nih.gov/pubmed/19625458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.013722-0
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