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Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model.

Rats bearing the Yoshida AH-130 ascites hepatoma showed enhanced fractional rates of protein degradation in gastrocnemius muscle, heart, and liver, while fractional synthesis rates were similar to those in non-tumor bearing rats. This hypercatabolic pattern was associated with marked perturbations o...

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Published in:J Clin Invest
Main Authors: Costelli, P, Carbó, N, Tessitore, L, Bagby, G J, Lopez-Soriano, F J, Argilés, J M, Baccino, F M
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1993
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288478/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8254032/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116897
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