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Improving draft assemblies by iterative mapping and assembly of short reads to eliminate gaps

Advances in sequencing technology allow genomes to be sequenced at vastly decreased costs. However, the assembled data frequently are highly fragmented with many gaps. We present a practical approach that uses Illumina sequences to improve draft genome assemblies by aligning sequences against contig...

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Autors principals: Tsai, Isheng J, Otto, Thomas D, Berriman, Matthew
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884544/
https://ncbi.nlm.nih.gov/pubmed/20388197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2010-11-4-r41
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