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Improving draft assemblies by iterative mapping and assembly of short reads to eliminate gaps

Advances in sequencing technology allow genomes to be sequenced at vastly decreased costs. However, the assembled data frequently are highly fragmented with many gaps. We present a practical approach that uses Illumina sequences to improve draft genome assemblies by aligning sequences against contig...

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Bibliografiske detaljer
Main Authors: Tsai, Isheng J, Otto, Thomas D, Berriman, Matthew
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884544/
https://ncbi.nlm.nih.gov/pubmed/20388197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2010-11-4-r41
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