Identification of the Function of Gene lndM2 Encoding a Bifunctional Oxygenase-Reductase Involved in the Biosynthesis of the Antitumor Antibiotic Landomycin E by Streptomyces globisporus 1912 Supports the Originally Assigned Structure for Landomycinone

[Image: see text] The angucycline antibiotic family of the landomycins displays potent antitumor activity. To elucidate early post polyketide synthase (PKS) tailoring steps of the landomycin E biosynthetic pathway in Streptomyces globisporus 1912, the mutant S. globisporus M12 was prepared through g...

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Detalhes bibliográficos
Main Authors: Zhu, Lili, Ostash, Bohdan, Rix, Uwe, Nur-e-Alam, Mohammad, Mayers, Almuth, Luzhetskyy, Andriy, Mendez, Carmen, Salas, Jose A., Bechthold, Andreas, Fedorenko, Victor, Rohr, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884283/
https://ncbi.nlm.nih.gov/pubmed/15651811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo0483623
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