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p75(NTR) Antagonistic Cyclic Peptide Decreases the Size of β Amyloid-Induced Brain Inflammation
Amyloid beta (Aβ) was shown to bind the 75 kD neurotrophin receptor (p75(NTR)) to induce neuronal death. We synthesized a p75(NTR) antagonistic peptide (CATDIKGAEC) that contains the KGA motif that is present in the toxic part of Aβ and closely resembles the binding site of NGF for p75(NTR). In vivo...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2884272/ https://ncbi.nlm.nih.gov/pubmed/18807174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10571-008-9298-6 |
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