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Induction of Premature Senescence by Hsp90 Inhibition in Small Cell Lung Cancer

BACKGROUND: The molecular chaperone Hsp90 is a promising new target in cancer therapy and selective Hsp90 inhibitors are currently in clinical trials. Previously these inhibitors have been reported to induce either cell cycle arrest or cell death in cancer cells. Whether the cell cycle arrest is rev...

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Detalhes bibliográficos
Main Authors: Restall, Ian J., Lorimer, Ian A. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884022/
https://ncbi.nlm.nih.gov/pubmed/20552022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011076
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