Activation of E. coli UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase by Fe(2+) yields a more efficient enzyme with altered ligand affinity

The metal-dependent deacetylase UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) catalyzes the first committed step in lipid A biosynthesis, the hydrolysis of UDP-3-O-myristoyl-N-acetyl-glucosamine to form UDP-3-O-myristoyl-glucosamine and acetate. Consequently, LpxC is a target...

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Main Authors: Hernick, Marcy, Gattis, Samuel G., Penner-Hahn, James E., Fierke, Carol A.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884013/
https://ncbi.nlm.nih.gov/pubmed/20136146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902066t
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