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Insulin-regulated Aminopeptidase Is a Key Regulator of GLUT4 Trafficking by Controlling the Sorting of GLUT4 from Endosomes to Specialized Insulin-regulated Vesicles

Insulin stimulates glucose uptake by regulating translocation of the GLUT4 glucose transporter from intracellular compartments to the plasma membrane. In the absence of insulin GLUT4 is actively sequestered away from the general endosomes into GLUT4-specialized compartments, thereby controlling the...

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Autors principals: Jordens, Ingrid, Molle, Dorothee, Xiong, Wenyong, Keller, Susanna R., McGraw, Timothy E.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883947/
https://ncbi.nlm.nih.gov/pubmed/20410133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-02-0158
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