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A sensitive and rapid liquid chromatography-tandem mass spectrometry method for the quantification of the novel neurokinin-1R antagonist aprepitant in rhesus macaque plasma, and cerebral spinal fluid, and human plasma with application in translational NeuroAIDs research

A sensitive and rapid liquid chromatography-tandem mass spectrometry method has been developed for the assessment of therapeutic exposures of aprepitant in HIV-infected patients and rhesus macaques. The method utilized a simple sample preparation procedure of protein precipitation with methanol. Chr...

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Detalhes bibliográficos
Main Authors: Wu, Di, Paul, Dustin J, Zhao, Xianguo, Douglas, Steven D, Barrett, Jeffrey S
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883891/
https://ncbi.nlm.nih.gov/pubmed/19167182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2008.12.005
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