Effect of danshen extract on the activity of CYP3A4 in healthy volunteers

AIMS: To assess the effect of danshen extract on CYP3A4 activity using midazolam as an in vivo probe. METHODS: A sequential, open-label, two-period pharmacokinetic interaction study design was used to compare midazolam pharmacokinetic parameters before and after 14 days of administration of danshen...

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Autors principals: Qiu, Furong, Wang, Guangji, Zhang, Rong, Sun, Jianguo, Jiang, Jian, Ma, Yueming
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2010
Matèries:
Drug Interactions
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883758/
https://ncbi.nlm.nih.gov/pubmed/20565457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03624.x
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