Pharmacokinetics and pharmacodynamics of nasally delivered midazolam

AIMS: To investigate the pharmacokinetics and pharmacodynamics of nasal formulations containing midazolam (5–30 mg ml(−1)) complexed with cyclodextrin. METHODS: An open-label sequential trial was conducted in eight healthy subjects receiving single doses of 1 mg and 3 mg intranasally and 1 mg midazo...

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Detalhes bibliográficos
Main Authors: Haschke, Manuel, Suter, Katja, Hofmann, Sarah, Witschi, Robert, Fröhlich, Johannes, Imanidis, Georgios, Drewe, Jürgen, Briellmann, Thomas A, Dussy, Franz E, Krähenbühl, Stephan, Surber, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883753/
https://ncbi.nlm.nih.gov/pubmed/20565452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03611.x
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