Decreased exposure to sunitinib due to concomitant administration of ifosfamide: results of a phase I and pharmacokinetic study on the combination of sunitinib and ifosfamide in patients with advanced solid malignancies

BACKGROUND: This study aimed to define the maximally tolerated dose (MTD) of sunitinib combined with two different infusion schedules of ifosfamide. METHODS: Patients with advanced solid tumours, good performance score, good organ function, and no standard therapy available were eligible. Continuous...

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Detalhes bibliográficos
Main Authors: Hamberg, P, Steeghs, N, Loos, W J, van de Biessen, D, den Hollander, M, Tascilar, M, Verweij, J, Gelderblom, H, Sleijfer, S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883699/
https://ncbi.nlm.nih.gov/pubmed/20485286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605696
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