Induction of cell death in neuroblastoma by inhibition of cathepsins B and L

A specific irreversible inhibitor of both cathepsins B and L, Fmoc-Tyr-Ala-CHN(2) (FYAD) induced apoptosis of neuroblastoma cells but not other tumor cells. Cysteine protease inhibitors that were not efficient inhibitors of both proteases did not cause death of any cell line tested. Apoptosis was pr...

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Detalhes bibliográficos
Main Authors: Colella, Rita, Lu, Guizhen, Glazewski, Lisa, Korant, Bruce, Matlapudi, Anjan, England, Matthew R, Craft, Colin, Frantz, Christopher N., Mason, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883669/
https://ncbi.nlm.nih.gov/pubmed/20362389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2010.01.037
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