I(f) and SR Ca(2+) release both contribute to pacemaker activity in canine sinoatrial node cells

Increasing evidence suggests that cardiac pacemaking is the result of two sinoatrial node (SAN) cell mechanisms: a ‘voltage clock’ and a Ca(2+) dependent process, or ‘Ca(2+) clock.’ The voltage clock initiates action potentials (APs) by SAN cell membrane potential depolarization from inward currents...

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Autori principali: Gao, Zhan, Chen, Biyi, Joiner, Mei-ling A., Wu, Yuejin, Guan, Xiaoqun, Koval, Olha M., Chaudhary, Ashok K., Cunha, Shane R., Mohler, Peter J., Martins, James B., Song, Long-Sheng, Anderson, Mark E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883640/
https://ncbi.nlm.nih.gov/pubmed/20380837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.03.019
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