A novel microtubule-modulating agent induces mitochondrially-driven caspase-dependent apoptosis via mitotic checkpoint activation in human prostate cancer cells

Hormone refractory prostate cancer, its skeletal metastasis and complications remain a therapeutic challenge. Here we show that treatment with (S)-3-((R)-9-bromo-4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-6,7-dimethoxyiso-benzofuran-1(3H)-one (EM011), the brominated a...

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Hlavní autoři: Aneja, Ritu, Miyagi, Tohru, Karna, Prasanthi, Ezell, Tucker, Shukla, Deep, Gupta, Meenakshi Vij, Yates, Clayton, Chinni, SR, Zhau, Haiyen, Chung, Leland W. K., Joshi, Harish C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883633/
https://ncbi.nlm.nih.gov/pubmed/20303260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2010.02.017
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