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CD73 on tumor cells impairs anti-tumor T cell responses: a novel mechanism of tumor-induced immune suppression

CD73, originally defined as a lymphocyte differentiation antigen, is thought to function as a co-signaling molecule on T lymphocytes and an adhesion molecule that is required for lymphocyte binding to endothelium. We show here that CD73 is widely expressed on many tumor cell lines and is upregulated...

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Main Authors: Jin, Dachuan, Fan, Jie, Wang, Long, Thompson, Linda F., Liu, Aijie, Daniel, Benjamin J., Shin, Tahiro, Curiel, Tyler J., Zhang, Bin
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883609/
https://ncbi.nlm.nih.gov/pubmed/20179192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3109
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