Functional Contribution of Elevated Circulating and Hepatic Non-Classical CD14(+)CD16(+) Monocytes to Inflammation and Human Liver Fibrosis

BACKGROUND: Monocyte-derived macrophages critically perpetuate inflammatory responses after liver injury as a prerequisite for organ fibrosis. Experimental murine models identified an essential role for the CCR2-dependent infiltration of classical Gr1/Ly6C(+) monocytes in hepatic fibrosis. Moreover,...

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Main Authors: Zimmermann, Henning W., Seidler, Sebastian, Nattermann, Jacob, Gassler, Nikolaus, Hellerbrand, Claus, Zernecke, Alma, Tischendorf, Jens J. W., Luedde, Tom, Weiskirchen, Ralf, Trautwein, Christian, Tacke, Frank
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883575/
https://ncbi.nlm.nih.gov/pubmed/20548789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011049
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