Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.

To extend previous observations on the role of polyamines in insulin production, metabolism, and replication of insulin-secreting pancreatic beta cells, we have studied the role of polyamines in the regulation of the stimulus-secretion coupling of clonal rat insulinoma cells (RINm5F). For this purpo...

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Bibliografische gegevens

Gepubliceerd in:	J Clin Invest
Hoofdauteurs:	Sjöholm, A, Arkhammar, P, Welsh, N, Bokvist, K, Rorsman, P, Hallberg, A, Nilsson, T, Welsh, M, Berggren, P O
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Clinical Investigation 1993
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288357/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8408643/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116784
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