Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.

To extend previous observations on the role of polyamines in insulin production, metabolism, and replication of insulin-secreting pancreatic beta cells, we have studied the role of polyamines in the regulation of the stimulus-secretion coupling of clonal rat insulinoma cells (RINm5F). For this purpo...

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Détails bibliographiques
Auteurs principaux: Sjöholm, A, Arkhammar, P, Welsh, N, Bokvist, K, Rorsman, P, Hallberg, A, Nilsson, T, Welsh, M, Berggren, P O
Format: Artigo
Langue:Inglês
Publié: 1993
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC288357/
https://ncbi.nlm.nih.gov/pubmed/8408643
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