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The Biological Effect of an Antisense Oligonucleotide Depends on Its Route of Endocytosis and Trafficking
We demonstrate that the biological effect of an oligonucleotide is influenced by its route of cellular uptake. Utilizing a splice-switching antisense oligonucleotide (SSO) and a sensitive reporter assay involving correction of RNA splicing, we examined induction of luciferase in cells treated either...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Mary Ann Liebert, Inc.
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2883474/ https://ncbi.nlm.nih.gov/pubmed/20038250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/oli.2009.0211 |
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