Efficient adenoviral-mediated ornithine transcarbamylase expression in deficient mouse and human hepatocytes.

100% of primary human hepatocytes infected with an adenoviral vector carrying beta-galactosidase expressed the exogenous gene. Expression was also achieved in > 40% of adult mouse hepatocytes in vivo. Normal levels of activity were achieved in mouse ornithine transcarbamylase (OTC)-deficient primary...

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Pubblicato in:	J Clin Invest
Autori principali:	Morsy, M A, Alford, E L, Bett, A, Graham, F L, Caskey, C T
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288307/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8376608/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116739
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