Mesd Is a Universal Inhibitor of Wnt Co-receptor LRP5/6 and Blocks Wnt/β-catenin Signaling in Cancer Cells

Mesd is a specialized chaperone for the low-density lipoprotein receptor-related protein-5 (LRP5) and LRP6. In our previous studies, we found that Mesd binds to mature LRP6 on the cell surface and blocks the binding of Wnt antagonist Dickkopf-1(Dkk1) to LRP6. Herein, we demonstrated that Mesd also b...

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Hlavní autoři: Lu, Wenyan, Liu, Chia-Chen, Thottassery, Jaideep V., Bu, Guojun, Li, Yonghe
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882879/
https://ncbi.nlm.nih.gov/pubmed/20446724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1001486
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