Constrained patterns of covariation and clustering of HIV-1 non-nucleoside reverse transcriptase inhibitor resistance mutations

OBJECTIVES: We characterized pairwise and higher order patterns of non-nucleoside reverse transcriptase inhibitor (NNRTI)-selected mutations because multiple mutations are usually required for clinically significant resistance to second-generation NNRTIs. PATIENTS AND METHODS: We analysed viruses fr...

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Autores principales: Reuman, Elizabeth C., Rhee, Soo-Yon, Holmes, Susan P., Shafer, Robert W.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2010
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882873/
https://ncbi.nlm.nih.gov/pubmed/20462946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkq140
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