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Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection
T cell selection and maturation in the thymus depends on the interactions between T cell receptors (TCRs) and different self-peptide–major histocompatibility complex (pMHC) molecules. We show that the affinity of the OT-I TCR for its endogenous positively selecting ligands, Catnb-H-2K(b) and Cappa1-...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2882826/ https://ncbi.nlm.nih.gov/pubmed/20457759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20092170 |
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