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The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells

A thymic epithelial cell line transfected with I-E(k) was used in reaggregate cultures to study the role of peptides in positive selection of T cell receptor transgenic thymocytes. In this system, positive selection of CD4 SP cells occurred only after the addition of exogenous peptide. Analysis of a...

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Autors principals: Wang, Rongfang, Nelson, Andrew, Kimachi, Kazuhiko, Grey, Howard M., Farr, Andrew G.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC19918/
https://ncbi.nlm.nih.gov/pubmed/9520448
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