Crystallization and preliminary X-ray diffraction analysis of the complex of a human anti-ephrin type-A receptor 2 antibody fragment and its cognate antigen

The recombinant N-terminal domain of human ephrin type-A receptor 2 (rEphA2) has been crystallized in complex with the recombinantly produced Fab fragment of a fully human antibody (1C1; IgG1/κ). These are the first reported crystals of an ephrin receptor bound to an antibody. The orthorhombic cryst...

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Bibliographic Details
Main Authors: Oganesyan, Vaheh, Damschroder, Melissa M., Phipps, Sandrina, Wilson, Susan D., Cook, Kimberly E., Wu, Herren, Dall’Acqua, William F.
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2010
Subjects:
Crystallization Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882782/
https://ncbi.nlm.nih.gov/pubmed/20516612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309110015861
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