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Very long-chain fatty acid accumulation causes lipotoxic response via 5-lipoxygenase in cerebral adrenoleukodystrophy

Abstract Childhood adrenoleukodystrophy (cALD) is a metabolic disorder in which very long-chain fatty acids (VLCFA) accumulate due to ALD protein gene defects, ultimately leading to lipotoxicity-induced neuroinflammatory demyelinating disease. Therefore, we examined VLCFA-mediated alterations in the...

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Main Authors: Khan, Mushfiquddin, Singh, Jaspreet, Gilg, Anne G., Uto, Takuhiro, Singh, Inderjit
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Biochemistry and Molecular Biology 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882744/
https://ncbi.nlm.nih.gov/pubmed/20173212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M002329
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