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p53 is required for chloroquine-induced atheroprotection but not insulin sensitization
An intact genotoxic stress response appears to be atheroprotective and insulin sensitizing. ATM, mutated in ataxia telangiectasia, is critical for the genotoxic stress response, and its deficiency is associated with accelerated atherosclerosis and insulin resistance in humans and mice. The antimalar...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The American Society for Biochemistry and Molecular Biology
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2882736/ https://ncbi.nlm.nih.gov/pubmed/20208057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M003681 |
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