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Liver-specific cytochrome P450 CYP2C22 is a direct target of retinoic acid and a retinoic acid-metabolizing enzyme in rat liver

Several cytochrome P450 (CYP) enzymes catalyze the C4-hydroxylation of retinoic acid (RA), a potent inducer of cell differentiation and an agent in the treatment of several diseases. Here, we have characterized CYP2C22, a member of the rat CYP2C family with homology to human CYP2C8 and CYP2C9. CYP2C...

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Detalhes bibliográficos
Main Authors: Qian, Linxi, Zolfaghari, Reza, Ross, A. Catharine
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882718/
https://ncbi.nlm.nih.gov/pubmed/20147703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M002840
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