A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation

Reactivation of silenced tumor suppressor genes by 5-azacytidine (Vidaza) and its congener 5-aza-2′-deoxycytidine (decitabine) has provided an alternate approach to cancer therapy. We have shown previously that these drugs selectively and rapidly induce degradation of the maintenance DNA methyltrans...

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Hlavní autoři: Datta, Jharna, Ghoshal, Kalpana, Denny, William A., Gamage, Swarna A., Brooke, Darby G., Phiasivongsa, Pasit, Redkar, Sanjeev, Jacob, Samson T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882697/
https://ncbi.nlm.nih.gov/pubmed/19417133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3669
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