The activation of factor X and prothrombin by recombinant factor VIIa in vivo is mediated by tissue factor.

The human coagulation system continuously generates very small quantities of Factor Xa and thrombin. Current evidence suggests that basal level activation of the hemostatic mechanism occurs via Factor VIIa-dependent activation of Factor X, but direct proof has not been available for the participatio...

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Detalles Bibliográficos

Publicado en:	J Clin Invest
Principais autores:	ten Cate, H, Bauer, K A, Levi, M, Edgington, T S, Sublett, R D, Barzegar, S, Kass, B L, Rosenberg, R D
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Clinical Investigation 1993
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288259/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8376580/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116691
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