The activation of factor X and prothrombin by recombinant factor VIIa in vivo is mediated by tissue factor.

The human coagulation system continuously generates very small quantities of Factor Xa and thrombin. Current evidence suggests that basal level activation of the hemostatic mechanism occurs via Factor VIIa-dependent activation of Factor X, but direct proof has not been available for the participatio...

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Bibliographic Details

Published in:	J Clin Invest
Main Authors:	ten Cate, H, Bauer, K A, Levi, M, Edgington, T S, Sublett, R D, Barzegar, S, Kass, B L, Rosenberg, R D
Format:	Artigo
Language:	Inglês
Published:	American Society for Clinical Investigation 1993
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288259/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8376580/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116691
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