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Thiol-disulfide effects on hepatic glutathione transport. Studies in cultured rat hepatocytes and perfused livers.

In cultured rat hepatocytes, cystine led to an inhibition of GSH efflux by lowering the Vmax by approximately 35% without affecting the Km. The cystine-mediated inhibition of GSH efflux was rapid in onset (< 1 h), with near maximum effect at 0.1 mM. Inhibition was still observed when cystine uptake...

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Udgivet i:J Clin Invest
Principais autores: Lu, S C, Ge, J L, Huang, H Y, Kuhlenkamp, J, Kaplowitz, N
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288257/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8376579/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116689
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