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Dissociation of CAK from Core TFIIH Reveals a Functional Link between XP-G/CS and the TFIIH Disassembly State

Transcription factor II H (TFIIH) is comprised of core TFIIH and Cdk-activating kinase (CAK) complexes. Here, we investigated the molecular and cellular manifestation of the TFIIH compositional changes by XPG truncation mutations. We showed that both core TFIIH and CAK are rapidly recruited to damag...

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Main Authors: Arab, Hany H., Wani, Gulzar, Ray, Alo, Shah, Zubair I., Zhu, Qianzheng, Wani, Altaf A.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882387/
https://ncbi.nlm.nih.gov/pubmed/20543986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011007
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