Plasminogen activator inhibitor-1 synthesis in the human hepatoma cell line Hep G2. Metformin inhibits the stimulating effect of insulin.

High plasma plasminogen activator inhibitor-1 (PAI-1) activity is associated with insulin resistance and is correlated with hyperinsulinemia. The cellular origin of plasma PAI-1 in insulin resistance is not known. The hepatoma cell line Hep G2 has been shown to synthesize PAI-1 in response to insuli...

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Vydáno v:	J Clin Invest
Hlavní autoři:	Anfosso, F, Chomiki, N, Alessi, M C, Vague, P, Juhan-Vague, I
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Clinical Investigation 1993
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288221/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8387542/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116445
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