The Legs at odd angles (Loa) Mutation in Cytoplasmic Dynein Ameliorates Mitochondrial Function in SOD1(G93A) Mouse Model for Motor Neuron Disease

Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal late-onset neurodegenerative disease. Familial cases of ALS (FALS) constitute ∼10% of all ALS cases, and mutant superoxide dismutase 1 (SOD1) is found in 15–20% of FALS. SOD1 mutations confer a toxic gain of unknown function to the prot...

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Detalhes bibliográficos
Main Authors: El-Kadi, Ali Morsi, Bros-Facer, Virginie, Deng, Wenhan, Philpott, Amelia, Stoddart, Eleanor, Banks, Gareth, Jackson, Graham S., Fisher, Elizabeth M. C., Duchen, Michael R., Greensmith, Linda, Moore, Anthony L., Hafezparast, Majid
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881788/
https://ncbi.nlm.nih.gov/pubmed/20382740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.129320
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