Cleavage of Survivin by Granzyme M Triggers Degradation of the Survivin-X-linked Inhibitor of Apoptosis Protein (XIAP) Complex to Free Caspase Activity Leading to Cytolysis of Target Tumor Cells

Granzyme M (GzmM) is a chymotrypsin-like serine protease that preferentially cuts its substrates after Met or Leu. GzmM is constitutively expressed in activated innate effector natural killer (NK) cells. GzmM-induced cell death is consistent with the kinetics of cytotoxicity of NK cells. These sugge...

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Detalhes bibliográficos
Main Authors: Hu, Deqing, Liu, Shengwu, Shi, Lei, Li, Chong, Wu, Lianfeng, Fan, Zusen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881758/
https://ncbi.nlm.nih.gov/pubmed/20406824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.083170
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