Neprilysin Impedes Islet Amyloid Formation by Inhibition of Fibril Formation Rather Than Peptide Degradation

Deposition of islet amyloid polypeptide (IAPP) as islet amyloid in type 2 diabetes contributes to loss of β-cell function and mass, yet the mechanism for its occurrence is unclear. Neprilysin is a metallopeptidase known to degrade amyloid in Alzheimer disease. We previously demonstrated neprilysin t...

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Bibliographic Details
Main Authors: Zraika, Sakeneh, Aston-Mourney, Kathryn, Marek, Peter, Hull, Rebecca L., Green, Pattie S., Udayasankar, Jayalakshmi, Subramanian, Shoba L., Raleigh, Daniel P., Kahn, Steven E.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881741/
https://ncbi.nlm.nih.gov/pubmed/20400513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.082032
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