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HDAC2 Promotes eIF4E Sumoylation and Activates mRNA Translation Gene Specifically

Histone deacetylases (HDACs) are best known as transcription corepressors through deacetylating histone tails. Here we show that HDAC2 is also involved in cap-dependent mRNA translation by promoting sumoylation of eukaryotic translation initiation factor 4E (eIF4E), which is independent of its deace...

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Detalhes bibliográficos
Main Authors: Xu, Xiang, Vatsyayan, Jaya, Gao, Chenxi, Bakkenist, Christopher J., Hu, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881737/
https://ncbi.nlm.nih.gov/pubmed/20421305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.131599
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