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Sumoylation of eIF4E activates mRNA translation

Eukaryotic translation initiation factor 4E (eIF4E) is the cap-binding protein that binds the 5′ cap structure of cellular messenger RNAs (mRNAs). Despite the obligatory role of eIF4E in cap-dependent mRNA translation, how the translation activity of eIF4E is controlled remains largely undefined. He...

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Detalhes bibliográficos
Main Authors: Xu, Xiang, Vatsyayan, Jaya, Gao, Chenxi, Bakkenist, Christopher J, Hu, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854592/
https://ncbi.nlm.nih.gov/pubmed/20224576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2010.18
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