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Phase II Clinical Trial of Sorafenib in Metastatic Medullary Thyroid Cancer
PURPOSE: Mutations in the RET proto-oncogene and vascular endothelial growth factor receptor (VEGFR) activity are critical in the pathogenesis of medullary thyroid cancer (MTC). Sorafenib, a multikinase inhibitor targeting Ret and VEGFR, showed antitumor activity in preclinical studies of MTC. PATIE...
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society of Clinical Oncology
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2881718/ https://ncbi.nlm.nih.gov/pubmed/20368568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.25.0068 |
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