Dietary fat increases high density lipoprotein (HDL) levels both by increasing the transport rates and decreasing the fractional catabolic rates of HDL cholesterol ester and apolipoprotein (Apo) A-I. Presentation of a new animal model and mechanistic studies in human Apo A-I transgenic and control mice.

In humans, diets high in saturated fat and cholesterol raise HDL-cholesterol (HDL-C) levels. To explore the mechanism, we have devised a mouse model that mimics the human situation. In this model, HuAITg and control mice were studied on low fat (9% cal)-low cholesterol (57 mg/1,000 kcal) (chow) and...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Hayek, T, Ito, Y, Azrolan, N, Verdery, R B, Aalto-Setälä, K, Walsh, A, Breslow, J L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288145/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8473509/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116375
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